Despite increased spending on research and development the number of new medic...Despite increased spending on research and development the number of new medicines marketed successfully continues to decline. The Pharmaceutical industry is therefore focussing on ways to reduce attrition by addressing frequent reasons for clinical...more
Natural Products have been important sources of useful drugs from prehistoric ...Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on...more
Genome- and proteome-based research is generating a significant increase in th...Genome- and proteome-based research is generating a significant increase in the number of available drug targets. Correspondingly there is an increasing need for novel diverse compounds particularly based on natural compounds as screening resource....more
The ErnstSchering Research Foundation sponsored its 15th workshop in Berlin o...The Ernst Schering Research Foundation sponsored its 15th workshop in Berlin on October 19-21 1994. Leading scientists from Europe and North America were invited to discuss computer-aided drug design in industrial research. Computer-aided drug...more
Metabolic research and especially that which focuses on the monooxygenase cyto...Metabolic research and especially that which focuses on the monooxygenase cytochrome P450 system has gone through dramatic progressive changes within the last decade. Availability of highly sophisticated analytical techniques has contributed to...more
Protein phosphorylation is an essential post-translational modification that m...Protein phosphorylation is an essential post-translational modification that modulates cell-cell communication. Substrate phosphorylation by protein kinases controls intracellular signal transduction pathways that mediate cell proliferation...more
New Strategies for CNS Repair.- Heterogeneity of Multiple Sclerosis: Implicati...New Strategies for CNS Repair.- Heterogeneity of Multiple Sclerosis: Implications for Therapy Targeting Regeneration.- The Neuroprotective Effect of Inflammation: Implications for the Therapy of Multiple Sclerosis.- Fibroblast Growth Factors in...more
Protein phosphorylation is an essential post-translational modification that m...Protein phosphorylation is an essential post-translational modification that modulates cell-cell communication. Substrate phosphorylation by protein kinases controls intracellular signal transduction pathways that mediate cell proliferation...more
The therapeutic options for the treatment of multiple sclerosis (MS) and other...The therapeutic options for the treatment of multiple sclerosis (MS) and other neurodegenerative and traumatic diseases such as spinal cord injury Alzheimer s Parkinson s disease etc. have undergone enormous progress over recent years. Despite these...more
With the excitement in the research and clinical communities over the potentia...With the excitement in the research and clinical communities over the potential of regenerative medicine scientists hope to develop novel therapies to target intractable degenerative diseases. In this book leading experts in the field present the...more
In modern drugdiscovery and development chemical synthesis is one of the key ...In modern drug discovery and development chemical synthesis is one of the key technologies. For the rapid preparation of new test compounds and drug development candidates several innovative technologies with great potential have emerged:...more
Pharmaceutical companies are spending increasing amounts of money on drug disc...Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless attrition rates in clinical development are still very high and up to 90% of new compounds fail in clinical phase I - III trials which...more
The discovery of mammalian nitric oxide (NO-) synthesis from I-ar- ginine has ...The discovery of mammalian nitric oxide (NO-) synthesis from I-ar- ginine has led to profound increases in our understanding of basic physiological and pathophysiological processes. This understanding has been achieved by major advances in several...more
Alzheimer s Disease is a progressive neurodegenerative disorder of late life w...Alzheimer s Disease is a progressive neurodegenerative disorder of late life with devastating consequences for the afflicted and their carers and poses one of the major challenges to medical research. Until recently little hope of effective...more
Personalized medicine employing patient-based tailor-made therapeutic drugs is...Personalized medicine employing patient-based tailor-made therapeutic drugs is taking over treatment paradigms in a variety of ?elds in oncology and the central nervous system. The success of such therapies is mainly dependent on ef?cacious...more